The current study, following a mixed-methods design, aimed at: 1) investigating whether internet-based applications including Adobe Connect and Shaad for online teaching could improve communication and vocabulary knowledge for pre-intermediate EFL learners, 2) examining if the difference varies with respect to the learners’gender and 3) detecting learners’ reactions to the role of online learning in improving their vocabulary knowledge. In doing so, 34 Iranian pre-intermediate EFL students were selected to take part in the study. The results of one-way ANCOVA confirmed that the Adobe Connect group outperformed the Shaad group with respect to vocabulary knowledge. As for gender, the results of the t-test confirmed that there was statistically no significant difference in students’ scores. The commonalities from the interviews indicated that it was a novel experience and a challenging task to learn new words. Finally, practical implications were offered for EFL students and teachers.