Vocabulary growth predicts communication ability and communication without vocabulary is impossible. The study was done among 50 EFL learners to examine the effect of music-based instruction on their vocabulary retention and attitudes. They were divided into experimental and control groups. First, a pre-test was conducted to fulfill the homogeneity assumption. Then, the photo dictionary part of the “English for Schools Prospect 1” book was set to music and the experimental group underwent music-based practices. While the control group received audio-visual instruction. Immediately after the instructions, a 20-item test was given to the groups. Subsequently, a 9-item attitude scale was distributed among the teacher, observer, and groups. After two weeks, a long-term memory test was conducted between the two groups. Results presented that the experimental group significantly outscored in the short- and long-term memory tests compared with the control group. Moreover, results from the attitude scale indicated that they welcomed music-based instruction allowing more profound vocabulary learning and communication ability than the audio-visual practices.